Recent progress in T-cadherin (CDH13, H-cadherin) research.

  title={Recent progress in T-cadherin (CDH13, H-cadherin) research.},
  author={Takako Takeuchi and Yoshiaki Ohtsuki},
  journal={Histology and histopathology},
  volume={16 4},
T-cadherin is a unique cadherin cell adhesion molecule that is anchored to the cell surface membrane through a glycosyl phosphatidyl inositol (GPI) moiety. The cytoplasmic domain, which T-cadherin lacks, is believed to be critical for homophilic binding through interaction with submembrane cytoskeletal proteins. Does this mean that T-cadherin is an unimportant molecule? However, the T-cadherin amino acid motif has been well conserved through evolution in vertebrates, suggesting that T-cadherin… CONTINUE READING


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