Recent perspectives in the diagnosis and evidence-based treatment of Mycoplasma genitalium

  title={Recent perspectives in the diagnosis and evidence-based treatment of Mycoplasma genitalium},
  author={Scott A. Weinstein and Bradley G. Stiles},
  journal={Expert Review of Anti-infective Therapy},
  pages={487 - 499}
Mycoplasma genitalium is a globally important sexually transmitted pathogen. Men infected with M. genitalium frequently present with dysuria, while women may present with or without urogenital symptoms. In some populations, M. genitalium is significantly associated with HIV-1 infection, and is also an etiological agent in pelvic inflammatory disease. However, there is insufficient evidence to establish a causative role of the organism in obstetric complications, including tubal factor… 
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Is Mycoplasma genitalium a cause of pelvic inflammatory disease?
  • J. Ross
  • Medicine
    Infectious disease clinics of North America
  • 2005
Mycoplasma genitalium: An Emerging Cause of Sexually Transmitted Disease in Women
Collectively, M. genitalium is highly prevalent in high- and low-risk populations, and should be considered an etiologic agent of select reproductive tract disease syndromes in women.
Diagnostic Assessment of Mycoplasma genitalium in Culture-Positive Women
Overall, it is shown that neither ELISA nor PCR, alone or in combination, provides the sensitivity required to confidently predict the existence of viable M. genitalium organisms in cervical and vaginal samples.
Mycoplasma genitalium: Is It a Sexually Transmitted Pathogen?
To assess whether M. genitalium is sexually transmitted, the literature was evaluated in terms of associations with established risk factors for other sexually transmitted infections, comparisons of sexually experienced individuals to nonsexually experienced individuals, consideration of other modes of transmission, assessment of concordant infection status among sexual partners, and examination of molecular strain typing in concordantly infected partners.
Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline
M genitalium is a common cause of persistent or recurrent urethritis among men treated with doxycycline and erythromycin appears to be less efficient than azithromycin in eradicating the infection.
Macrolide Resistance–associated 23S rRNA Mutation in Mycoplasma genitalium, Japan
Mycoplasma genitalium DNA found in the urine of men with NGU was examined for the presence of macrolide resistance–associated mutations in the 23S rRNA gene and the ribosomal protein genes L4 and L22.
High Prevalence of Mycoplasma genitalium in the Lower Genitourinary Tract of Women Attending a Sexually Transmitted Disease Clinic in Paris, France
It is indicated that M genitalium is frequently encountered in the female genital tract and is not associated with cervicitis or any particular clinical or microbiologic data.
Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease
M genitalium is associated with endometritis and short-term PID treatment failure and cefoxitin and doxycycline, a Centers for Disease Control and Prevention recommended PID treatment regimen, is ineffective for the treatment of M genitalium upper genital tract infection.
Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial
Analysis of in- vivo and in-vitro data from the literature of fluoroquinolone efficacies against M genitalium suggests that a MIC90 of 0.125 μg/ml or less may be useful for optimal activity against M penis-related urethritis.
Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workers
M genitalium is weakly associated with signs of cervicitis in west African FSW but is highly prevalent, while N gonorrhoeae was strongly and independently associated with each of the four signs of cervical cancer.