Recent perspectives in the diagnosis and evidence-based treatment of Mycoplasma genitalium

@article{Weinstein2012RecentPI,
  title={Recent perspectives in the diagnosis and evidence-based treatment of Mycoplasma genitalium},
  author={Scott A. Weinstein and Bradley G. Stiles},
  journal={Expert Review of Anti-infective Therapy},
  year={2012},
  volume={10},
  pages={487 - 499}
}
Mycoplasma genitalium is a globally important sexually transmitted pathogen. Men infected with M. genitalium frequently present with dysuria, while women may present with or without urogenital symptoms. In some populations, M. genitalium is significantly associated with HIV-1 infection, and is also an etiological agent in pelvic inflammatory disease. However, there is insufficient evidence to establish a causative role of the organism in obstetric complications, including tubal factor… 
View on Taylor & Francis
ncbi.nlm.nih.gov
18 Citations
Background Citations
8

18 Citations

Mycoplasma genitalium: a review
TLDR
The association of M. genitalium with non-specific urethritis is now well established, but the evidence supporting its role in both male and female infertility remains inconclusive and the recommended treatment is azithromycin as a single 1 gm dose.
Antimicrobial susceptibility of Mycoplasma genitalium isolates from Pretoria, South Africa in 2012 and 2016
TLDR
This study compared the genotypic macrolide and fluoroquinolone resistance of M. genitalium strains obtained from women attending a termination of pregnancy clinic five years apart to detect the presence of the pathogen by PCR in vaginal swab samples from two tertiary hospitals in Pretoria, South Africa.
Mycoplasma genitalium Detection in Urogenital Specimens from Symptomatic and Asymptomatic Men and Women by Use of the cobas TV/MG Test
TLDR
The cobas assay was highly sensitive and specific in all relevant clinical samples for the detection of M. genitalium, and was compared to a reference standard of three laboratory-developed tests.
Prevalence and correlates of Mycoplasma genitalium infection among prostatitis patients in Shanghai, China.
TLDR
M. genitalium was prevalent in the patients with prost atitis, particularly in those who received ineffective antibiotic treatment for the bacterium, and was identified as having a significant association of prostatitis.
Urogenital mycoplasmosis and pregnancy
TLDR
Screening of asymptomatic patients for M. parvum and M. hominis is currently still not indicated, and studies have shown that antibiotics resistance is on the rise and differs considerably by regions.
Screening for Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium should it be integrated into routine pregnancy care in French young pregnant women?
Patients with cervical Ureaplasma Urealyticum and Chlamydia Trachomatis infection undergoing IVF/ICSI-ET: The need for new paradigm
TLDR
Cervical UU and CT infections were the risk factors for ectopic pregnancy and tubal factor-induced infertility and the pregnancy rate, abortion rate, ectopicregnancy rate and premature birth rate in patients with UU/or CT infections showed no significant difference when compared with the control group.
Epidemiology of Mycoplasma genitalium in British men and women aged 16–44 years: evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)
TLDR
This study strengthens evidence that MG is an STI, identified in over 1% of the population, including in men with high-risk behaviours in older age groups that are often not included in STI prevention measures.
Deciphering host-pathogen interactions at the biomembrane interface, key to target therapeutical approaches against Mycoplasma genitalium
TLDR
The focus of this project is to find likely therapeutical targets against the infection by M.genitalium to Homo sapiens by analysing the membrane proteome of several strains and near species of the bacterium and calculating their evolutionary rate.
Diagnostic Approaches to Genitourinary Tract Infections
TLDR
Failure to diagnose and cure people with urethral and vaginal infections is associated with patient morbidity and mortality and can facilitate the continued transmission of infections to partners and from mother to infant during birth.
...
...

References

SHOWING 1-10 OF 147 REFERENCES
Is Mycoplasma genitalium a cause of pelvic inflammatory disease?
  • J. Ross
  • Medicine
    Infectious disease clinics of North America
  • 2005
Mycoplasma genitalium: An Emerging Cause of Sexually Transmitted Disease in Women
TLDR
Collectively, M. genitalium is highly prevalent in high- and low-risk populations, and should be considered an etiologic agent of select reproductive tract disease syndromes in women.
Diagnostic Assessment of Mycoplasma genitalium in Culture-Positive Women
TLDR
Overall, it is shown that neither ELISA nor PCR, alone or in combination, provides the sensitivity required to confidently predict the existence of viable M. genitalium organisms in cervical and vaginal samples.
Mycoplasma genitalium: Is It a Sexually Transmitted Pathogen?
TLDR
To assess whether M. genitalium is sexually transmitted, the literature was evaluated in terms of associations with established risk factors for other sexually transmitted infections, comparisons of sexually experienced individuals to nonsexually experienced individuals, consideration of other modes of transmission, assessment of concordant infection status among sexual partners, and examination of molecular strain typing in concordantly infected partners.
Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline
TLDR
M genitalium is a common cause of persistent or recurrent urethritis among men treated with doxycycline and erythromycin appears to be less efficient than azithromycin in eradicating the infection.
Macrolide Resistance–associated 23S rRNA Mutation in Mycoplasma genitalium, Japan
TLDR
Mycoplasma genitalium DNA found in the urine of men with NGU was examined for the presence of macrolide resistance–associated mutations in the 23S rRNA gene and the ribosomal protein genes L4 and L22.
High Prevalence of Mycoplasma genitalium in the Lower Genitourinary Tract of Women Attending a Sexually Transmitted Disease Clinic in Paris, France
TLDR
It is indicated that M genitalium is frequently encountered in the female genital tract and is not associated with cervicitis or any particular clinical or microbiologic data.
Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease
TLDR
M genitalium is associated with endometritis and short-term PID treatment failure and cefoxitin and doxycycline, a Centers for Disease Control and Prevention recommended PID treatment regimen, is ineffective for the treatment of M genitalium upper genital tract infection.
Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial
TLDR
Analysis of in- vivo and in-vitro data from the literature of fluoroquinolone efficacies against M genitalium suggests that a MIC90 of 0.125 μg/ml or less may be useful for optimal activity against M penis-related urethritis.
Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workers
TLDR
M genitalium is weakly associated with signs of cervicitis in west African FSW but is highly prevalent, while N gonorrhoeae was strongly and independently associated with each of the four signs of cervical cancer.
...
...