Recent perspectives in brain tumor biology and treatment.

  title={Recent perspectives in brain tumor biology and treatment.},
  author={Mark L. Rosenblum and Michael E. Berens and James T. Rutka},
  journal={Clinical neurosurgery},
Tumors are composed of tumor cells, normal host cells, and an ECM. Tumor growth depends on the balance between tumor cell proliferation and tumor cell loss and is significantly influenced by normal vascular, immune, and glial cells of the host. Furthermore, tumor size and growth regulation are probably influenced by components of the ECM and by edema within and surrounding the tumor. To increase the therapeutic value of treatment regimens, investigators must study normal tissues and attempt to… CONTINUE READING
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