Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma

@article{Fujii2017RecentMS,
  title={Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma},
  author={Kiyonaga Fujii and Haruhiko Nakamura and Toshihide Nishimura},
  journal={Expert Review of Proteomics},
  year={2017},
  volume={14},
  pages={373 - 386}
}
ABSTRACT Introduction: Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made it possible to analyze disease-relevant proteins expressed in clinical specimens by proteomic challenges. Areas covered: To understand the molecular mechanisms of lung… 
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37 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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37 Citations

Quantitative proteomics in lung cancer
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Both theoretical and practical applications in the use of quantitative proteomics approaches are introduced, with principles of current technologies and methodologies including gel-based, label free, stable isotope labeling as well as targeted proteomics.
Recent insights into human bronchial proteomics – how are we progressing and what is next?
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The recent achievements and discoveries in human bronchial proteomics are overviewed by outlining how some of the different proteomic techniques/strategies are developed and applied in LC, TB, COPD, and CF and the future roles of bronchia proteomics in predictive proteomics and precision medicine are discussed.
Searching for biomarkers of chronic obstructive pulmonary disease using proteomics: The current state
TLDR
The results in this area published over the past decade show that proteomics indeed has the ability of monitoring alterations in expression profiles of proteins from fluids/tissues of patients affected by COPD and healthy controls, but suggest that it remains a technique mainly generated and developed in research laboratories.
Current status of clinical proteogenomics in lung cancer
TLDR
A large-scale, MS-based, proteomic analysis, together with both NGS-based genomic data and clinicopathological information, will facilitate establishing extensive databases for lung cancer subtypes that can be used for further proteogenomic analyzes.
Current Insights on the Impact of Proteomics in Respiratory Allergies
TLDR
Proteomics has enabled the establishment of several proteins for diagnosing and treating respiratory allergic diseases, and the principal goal of proteomics has been to discover new proteins and use them in precision medicine.
Role of respiratory proteomics in precision medicine
Mass spectrometry based proteomics and metabolomics in personalized oncology.
Glycoprotein biomarkers and analysis in chronic obstructive pulmonary disease and lung cancer with special focus on serum immunoglobulin G.
Molecular insights into cancer drug resistance from a proteomics perspective
TLDR
This work reviews the recent advances and challenges in proteomics studies on cancer drug resistance with an emphasis on biomarker discovery, as well as understanding the interconnectivity of proteins in disease-related signaling pathways, and highlights the critical role that post-translational modifications (PTMs) play in the mechanisms of cancerdrug resistance.
Untargeted metabolomics of human plasma reveal lipid markers unique to chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
TLDR
It is demonstrated that COPD and IPF were characterised by systemic changes in lipid constituents such as essential FA sampled from circulating plasma, and dihydrotestosterone was lower in both diseases.
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