Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.

@article{Gianchecchi2013RecentII,
  title={Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.},
  author={E. Gianchecchi and D. Delfino and A. Fierabracci},
  journal={Autoimmunity reviews},
  year={2013},
  volume={12 11},
  pages={
          1091-100
        }
}
Autoimmune diseases represent a heterogeneous group of conditions whose incidence is increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a complex interaction between genetic and environmental factors, in order to improve prevention and treatment of these disorders. The relevance of T regulatory cells and of the PD-1/PD-L1 pathway in controlling immune responses has been highlighted. Recent studies have in particular elucidated the putative role of the PD-1… Expand
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