Recent insights into the pathogenesis of hyperuricaemia and gout.

@article{Riches2009RecentII,
  title={Recent insights into the pathogenesis of hyperuricaemia and gout.},
  author={Philip L. Riches and Alan F. Wright and Stuart H. Ralston},
  journal={Human molecular genetics},
  year={2009},
  volume={18 R2},
  pages={R177-84}
}
Gout is a common rheumatic disease in humans which is characterized by elevation in serum uric acid levels, and deposition of uric acid crystals in the joint. Hyperuricaemia is the primary risk factor for the development of gout and primates have uniquely high levels of serum uric acid due to missense mutations in the uricase gene. Levels of serum uric acid are known to be highly heritable, and mutations in genes which encode enzymes in the purine salvage pathway have long been recognized as… CONTINUE READING

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