Recent insights into stearoyl-CoA desaturase-1

  title={Recent insights into stearoyl-CoA desaturase-1},
  author={James M. Ntambi and Makoto Miyazaki},
  journal={Current Opinion in Lipidology},
Purpose of review Stearoyl-Coenzyme A (CoA) desaturase is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids - mainly oleate (C18:1). Oleate is the most abundant monounsaturated fatty acid in dietary fat and is therefore readily available. Why, then, is stearoyl-CoA desaturase a highly regulated enzyme? This review summarizes the recent and timely advances concerning the important role of stearoyl-CoA desaturase in metabolism. Recent findings Recent findings… 

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

Modulation of stearoyl-coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly influences several facets of energy metabolism to affect susceptibility to obesity, insulin resistance, diabetes and hyperlipidemia.

Regulation of stearoyl-CoA desaturase expression

Why SCD is such a highly regulated enzyme even though oleate, the major product of this enzyme, is one of the most abundant FA in the diet and is therefore readily available is investigated.

Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity.

The role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity is evaluated and its prospects as a potential drug target for the management of obesity and related disorders are explored.

Stearoyl‐CoA desaturase as a new drug target for obesity treatment

  • A. DobrzyńJ. Ntambi
  • Medicine, Biology
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2005
It is shown that SCD1‐deficient mice have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet‐induced obesity and liver steatosis, and that pharmacological manipulation of SCD activity might be of benefit in the treatment of obesity, diabetes, liver Steatosis and other diseases of the metabolic syndrome.

The role of stearoyl-CoA desaturase in the control of metabolism.

The role of stearoyl-CoA desaturase in body weight regulation.

Stearoyl CoA desaturase 1: role in cellular inflammation and stress.

This review summarizes the current understanding of the role of SCD1 in modulating inflammation and stress and states that normal cellular function requires the expression ofSCD1 to be tightly controlled.



Role of stearoyl-coenzyme A desaturase in lipid metabolism.

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity

  • J. NtambiM. Miyazaki A. Attie
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
It is shown that mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain, suggesting that a consequence ofSCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.

Regulation of stearoyl-CoA desaturase genes: role in cellular metabolism and preadipocyte differentiation.

The role of the SCD isoforms in metabolism and the recent findings on the differential regulation of mouse SCD genes by the antidiabetic thiazolidinediones (TZDs), during preadipocyte differentiation are discussed.

Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse.

The observations demonstrate that loss of SCD1 function alters the expression ofSCD3 and reveal for the first time the presence and regulation of a palmitoyl-CoA Delta6 desaturase enzyme in mammals.

The regulation of stearoyl-CoA desaturase (SCD).

  • J. Ntambi
  • Biology
    Progress in lipid research
  • 1995

Glucose induces expression of stearoyl-CoA desaturase in 3T3-L1 adipocytes.

It is found that glucose availability directly increased SCD gene scription in 3T3-L1 adipocytes and this response was pendent of insulin, and insulin alone in the absence of glucose had no effect on SCD mRNA levels.

Regulation of hepatic stearoyl-CoA desaturase gene 1 by vitamin A.

The effect of vitamin A supplementation on stearoyl-CoA desaturase gene 1 expression in mouse liver was characterized and suggests that the retinoic acid receptor transcriptionally regulates SCD1 through a traditional mechanism of heterodimerization with the retinoid X receptor.

Oleoyl-CoA Is the Major de Novo Product of Stearoyl-CoA Desaturase 1 Gene Isoform and Substrate for the Biosynthesis of the Harderian Gland 1-Alkyl-2,3-diacylglycerol*

It is demonstrated that SCD1-synthesized oleoyl-CoA is a major substrate required for the biosynthesis of normal levels of ADG and that the SCD isoforms present in the HG have different substrate specificity.