Recent insights into stearoyl-CoA desaturase-1

@article{Ntambi2003RecentII,
  title={Recent insights into stearoyl-CoA desaturase-1},
  author={James M. Ntambi and Makoto Miyazaki},
  journal={Current Opinion in Lipidology},
  year={2003},
  volume={14},
  pages={255-261}
}
Purpose of review Stearoyl-Coenzyme A (CoA) desaturase is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids - mainly oleate (C18:1). Oleate is the most abundant monounsaturated fatty acid in dietary fat and is therefore readily available. Why, then, is stearoyl-CoA desaturase a highly regulated enzyme? This review summarizes the recent and timely advances concerning the important role of stearoyl-CoA desaturase in metabolism. Recent findings Recent findings… 

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

Modulation of stearoyl-coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly influences several facets of energy metabolism to affect susceptibility to obesity, insulin resistance, diabetes and hyperlipidemia.

Regulation of stearoyl-CoA desaturase expression

Why SCD is such a highly regulated enzyme even though oleate, the major product of this enzyme, is one of the most abundant FA in the diet and is therefore readily available is investigated.

Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity.

The role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity is evaluated and its prospects as a potential drug target for the management of obesity and related disorders are explored.

Stearoyl‐CoA desaturase as a new drug target for obesity treatment

  • A. DobrzyńJ. Ntambi
  • Medicine, Biology
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2005
It is shown that SCD1‐deficient mice have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet‐induced obesity and liver steatosis, and that pharmacological manipulation of SCD activity might be of benefit in the treatment of obesity, diabetes, liver Steatosis and other diseases of the metabolic syndrome.

The role of stearoyl-CoA desaturase in the control of metabolism.

The role of stearoyl-CoA desaturase in body weight regulation.

Stearoyl CoA desaturase 1: role in cellular inflammation and stress.

This review summarizes the current understanding of the role of SCD1 in modulating inflammation and stress and states that normal cellular function requires the expression ofSCD1 to be tightly controlled.
...

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