Recent insights into Clostridium difficile pathogenesis.

  title={Recent insights into Clostridium difficile pathogenesis.},
  author={Alex G. Peniche and Tor C. Savidge and Sara M. Dann},
  journal={Current opinion in infectious diseases},
  volume={26 5},
PURPOSE OF REVIEW Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in the healthcare setting. An emerging consensus suggests that CDI is caused by pathogenic toxin production, gut microbial dysbiosis and altered host inflammatory responses. The aim of this review is to summarize and highlight recent advances focused on CDI pathogenic mechanisms. RECENT FINDINGS Potential paradigm shifts relating to the mechanisms of… CONTINUE READING
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