Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.

@article{Wessels2007RecentII,
  title={Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.},
  author={Judith A. M. Wessels and Thomas W. J. Huizinga and H-J. Guchelaar},
  journal={Rheumatology},
  year={2007},
  volume={47 3},
  pages={
          249-55
        }
}
This review presents recent data supporting the methotrexate (MTX) mechanisms of action, which are likely to account for its anti-proliferative and immunosuppressive effects in rheumatoid arthritis (RA). The effects of MTX in vivo may be mediated by reducing cell proliferation, increasing the rate of apoptosis of T cells, increasing endogenous adenosine release, altering the expression of cellular adhesion molecules, influencing production of cytokines, humoral responses and bone formation… 
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67 References

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