Recent insight into obesity and asthma

  title={Recent insight into obesity and asthma},
  author={David A. Beuther},
  journal={Current Opinion in Pulmonary Medicine},
  • D. Beuther
  • Published 1 January 2010
  • Medicine, Biology
  • Current Opinion in Pulmonary Medicine
Purpose of review The worldwide pandemic of obesity is creating unique challenges for the diagnosis and treatment of asthma. A wealth of epidemiologic literature has established that whereas asthma can lead to obesity, obesity is a risk factor for asthma, but mechanisms are unclear. This review assesses the current understanding of the relationship between obesity and asthma. Recent findings Recent studies are developing a more sophisticated understanding of the possible inflammatory… 
Emerging interface between metabolic syndrome and asthma.
The current understanding of the potential mechanistic links between obesity and asthma is reviewed, emphasizing the potential influence of metabolic abnormalities on asthmatic processes, therapeutic implications, and expected challenges.
Mitochondrial Dysfunction in Metabolic Syndrome and Asthma
Current understanding of the overlapping features between metabolic syndrome and asthma in relation to mitochondrial structural and functional alterations is discussed with an aim to uncover mechanisms for obese-asthma.
Obesity and pulmonary disease: unanswered questions
Obesity is associated with risk of pulmonary disease, and adversely affects lung function. The parallel increase in obesity and asthma suggests the two conditions are linked; indeed, they can worsen
Asthma and endocrine disorders: Shared mechanisms and genetic pleiotropy
The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study
There is no relationship between obesity and bronchial hyperresponsiveness and atopy in chronic cough patients, and the nonobese group appears to have more atopy.
Obesity and asthma
It has been a matter of interest for researchers to find a relation between asthma and obesity and to assess the impact of management of obesity on asthma symptoms.
[Asthma and obesity: relationship and therapeutic implications in patients with asthma at the Department of Pneumology in Monastir, Tunisia].
Introduction Obesity and asthma are two chronic diseases affecting millions of people around the world. A causal relationship has been suggested. The purpose of our study is to examine the profile in
Obesity, metabolic syndrome, and airway disease: a bioenergetic problem?


The epidemiology of obesity and asthma.
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  • Medicine
    The Journal of allergy and clinical immunology
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The association between obesity and asthma: interactions between systemic and airway inflammation.
The link between obesity and asthma is unlikely to be explained by enhancement of the "classical" forms of airway inflammation resulting from the systemic inflammatory effects of obesity itself, and other mechanisms, possibly related to innate immunity, may explain the relationship between Obesity and asthma.
Asthma-Like Symptoms are Increased in the Metabolic Syndrome
  • Eun Joo Lee, K. In, S. Yoo
  • Medicine
    The Journal of asthma : official journal of the Association for the Care of Asthma
  • 2009
It is hypothesized that metabolic syndrome is an important contributing factor for the development of asthma-like symptoms, and among the components of metabolic syndrome, abdominal obesity and hypertension are the risk factors for asthma- like symptoms.
Obesity and asthma: a specific phenotype?
Bronchial and systemic inflammatory characteristics and the specific pattern of pulmonary function changes suggest a different phenotype of asthma in these subjects, which was poorer in obese subjects than in nonobese subjects.
Weight loss and asthma: a systematic review
A systematic review based on searches between January 1966 and January 2007 of both PubMed and the Cochrane Clinical Trial Database found that of the 15 relevant studies, asthma was the primary outcome in only five and all 15 studies noted an improvement in at least one asthma outcome after weight loss.
Are Genes Associated with Energy Metabolism Important in Asthma and BMI?
Polymorphisms of the leptin gene may be associated with asthma and higher BMI in asthmatic patients and the results of haplotype analysis for the LEPR gene may suggest a protective role of the GG haplotype against asthma; however, studies on larger groups are necessary to confirm the observed trend towards association.
Relationship between adipokines and manifestations of childhood asthma
The findings suggest that resistin may play a negative predictive role in asthma and leptin and adiponectin showed close associations with pulmonary function and may have disease‐modifying effects in children with asthma.
Association between asthma and serum adiponectin concentration in women
A high serum adiponectin concentration may protect against current asthma in premenopausal women but does not explain the association between asthma and adiposity.