Recent findings on the pharmacokinetics of non-steroidal anti-inflammatory drugs in synovial fluid.

@article{Netter1989RecentFO,
  title={Recent findings on the pharmacokinetics of non-steroidal anti-inflammatory drugs in synovial fluid.},
  author={Patrick Netter and Bernard Bannwarth and Marie Jos{\'e} Royer-Morrot},
  journal={Clinical pharmacokinetics},
  year={1989},
  volume={17 3},
  pages={145-62}
}
Synovial fluid concentration is considered to be an important determinant of clinical response to non-steroidal anti-inflammatory drugs (NSAIDs). Trans-synovial transport of these drugs is a process of limited diffusion, governed partly by the pharmacological characteristics of NSAIDs and partly by the properties of the joint and joint space themselves. The studies which report simultaneous pharmacokinetics of NSAIDs in both plasma and synovial fluid compartments are of 2 types: (1) some… CONTINUE READING