Recent evolution of equine influenza and the origin of canine influenza.

  title={Recent evolution of equine influenza and the origin of canine influenza.},
  author={Patrick J. Collins and Sebastien G. Vachieri and Lesley F. Haire and Roksana W Ogrodowicz and Stephen R. Martin and Philip A. Walker and Xiaoli Xiong and Steven J. Gamblin and John J. Skehel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 30},
In 2004 an hemagglutinin 3 neuraminidase 8 (H3N8) equine influenza virus was transmitted from horses to dogs in Florida and subsequently spread throughout the United States and to Europe. To understand the molecular basis of changes in the antigenicity of H3 hemagglutinins (HAs) that have occurred during virus evolution in horses, and to investigate the role of HA in the equine to canine cross-species transfer, we used X-ray crystallography to determine the structures of the HAs from two… CONTINUE READING
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