Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease.

  title={Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease.},
  author={Edward A. Monaco},
  journal={Current Alzheimer research},
  volume={1 1},
Based on a growing literature, cyclin-dependent kinase 5 (Cdk5) has been implicated in the pathological processes that contribute to neurodegeneration in Alzheimer's disease (AD). Cdk5 is ubiquitously expressed, but its activity is largely localized to post-mitotic neurons due to neuron-specific expression of its activators p35 and p39. Sufficient Cdk5 activity is critical to normal central nervous system development, as in its absence, neuronal migration and axonal path finding are deranged… CONTINUE READING


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