Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer.

@article{Bera2016RecentDO,
  title={Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer.},
  author={Hriday Bera and Sridevi Chigurupati},
  journal={European journal of medicinal chemistry},
  year={2016},
  volume={124},
  pages={992-1003}
}
Thymidine phosphorylase (TP, EC 2.4.2.4), an enzyme involved in pyrimidine salvage pathway, is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. It is extremely upregulated in a variety of solid tumours. The TP amplification is associated with concomitant overexpression of many angiogenic factors such as matrix… CONTINUE READING