Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1.

@article{Siliciano2014RecentDI,
  title={Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1.},
  author={Janet D Siliciano and Robert F. Siliciano},
  journal={The Journal of allergy and clinical immunology},
  year={2014},
  volume={134 1},
  pages={12-9}
}
HIV-1 infection can now be readily controlled with combination antiretroviral therapy. However, the virus persists indefinitely in a stable latent reservoir in resting CD4(+) T cells. This reservoir generally prevents cure of the infection with combination antiretroviral therapy alone. However, several recent cases of potential HIV-1 cure have generated renewed optimism. Here we review these cases and consider new developments in our understanding of the latent reservoir. In addition, we… CONTINUE READING

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