Recent developments in the immunology of inflammatory bowel disease.

  title={Recent developments in the immunology of inflammatory bowel disease.},
  author={Thomas Macdonald and Giovanni Monteleone and Sylvia L. F. Pender},
  journal={Scandinavian journal of immunology},
  volume={51 1},
Crohn's disease and ulcerative colitis are caused by excessive immune reactivity in the gut wall. Analysis of the type of immune responses ongoing in diseased gut has revealed important features which suggest that these conditions are different. In Crohn's disease tissue there is considerable evidence for an ongoing T helper cell type 1 response, with excess interleukin-12, interferon-gamma and TNF-alpha. There is circumstantial evidence in patients that this response is directed against the… CONTINUE READING