Recent developments in the chemistry of potassium channel activators: the cromakalim analogs.

@article{Sebille2004RecentDI,
  title={Recent developments in the chemistry of potassium channel activators: the cromakalim analogs.},
  author={Sophie Sebille and Pascal De Tullio and S. Boverie and Meester Antoine and Philippe Lebrun and Bernard Pirotte},
  journal={Current medicinal chemistry},
  year={2004},
  volume={11 9},
  pages={
          1213-22
        }
}
Potassium channels play a crucial role in controlling the cell membrane potential. Among the different varieties of K(+) channels, the ATP-sensitive potassium channels (K(ATP) channels) have been characterized in numerous cell types, such as skeletal and smooth muscle cells, endocrine cells, cardiac cells and central neurons. Several molecules are known to activate K(ATP) channels and have been named "potassium channel openers" (PCOs). Such compounds may have a wide therapeutic potential and a… CONTINUE READING