Recent developments in the assessment of chromosomal damage.

  title={Recent developments in the assessment of chromosomal damage.},
  author={Adayapalam Tyagarajan Natarajan and Adayabalam S. Balajee and Jan J. W. A. Boei and Sandipan Chatterjee and Firouz Darroudi and Mira Grigorova and M Noditi and Hyun Ju Oh and Predrag Slijepcevic and Stefan Vermeulen},
  journal={International journal of radiation biology},
  volume={66 5},
Ionizing radiation and restriction endonucleases are very efficient in inducing chromosomal aberrations (CAs). These aberrations are mainly consequences of misrepair of DNA double-strand breaks (DSBs). The fast repairing component of DSBs induced by ionizing radiation seems to be responsible for exchange aberration. Use of premature chromosome condensation technique in combination with DNA repair inhibitors such as ara A has given valuable information on the assessment of the frequencies of… CONTINUE READING