Recent developments in superporous hydrogels

@article{Omidian2007RecentDI,
  title={Recent developments in superporous hydrogels},
  author={Hossein Omidian and Kinam Park and Jose G. Rocca},
  journal={Journal of Pharmacy and Pharmacology},
  year={2007},
  volume={59}
}
Superporous hydrogels (SPHs) were originally developed as a novel drug delivery system to retain drugs in the gastric medium. These systems should instantly swell in the stomach and maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. For years, the synthetic features and properties of these SPH materials have been modified and improved to meet the requirements for gastric retention applications. Furthermore, an instant swelling… 
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Swelling and Mechanical Properties of Modified HEMA-based Superporous Hydrogels
Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ion-complexable hydrophilic acrylic acid. PHEMA SPHs are generally…
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References

SHOWING 1-10 OF 60 REFERENCES
Advances in superporous hydrogels.
Gastric retention properties of superporous hydrogel composites.
Synthesis and characterization of superporous hydrogel composites.
  • J. Chen, K. Park
  • Materials Science, Engineering
    Journal of controlled release : official journal of the Controlled Release Society
  • 2000
Elastic, superporous hydrogel hybrids of polyacrylamide and sodium alginate.
TLDR
A hydrogel hybrid of acrylamide and alginate shows resilience and a rubbery property in its fully water-swollen state, which not previously been reported.
Synthesis of fast-swelling, superporous sucrose hydrogels.
Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties.
TLDR
The superporous hydrogels can be used where fast swelling and superabsorbent properties are critical and the equilibrium swelling time could be reduced to less than a minute with the use of a wetting agent.
Preparation and swelling behavior of chitosan-based superporous hydrogels for gastric retention application.
TLDR
The prepared superporous hydrogels were highly sensitive to pH of swelling media, and showed reversible swelling and de-swelling behaviors maintaining their mechanical stability.
Control of the Swelling Rate of Superporous Hydrogels
Superporous hydrogels (SPHs) have a fast swelling property because of the presence of interconnected pores. While the fast swelling property is an advantage, sometimes it is necessary to control the…
pH-sensitivity of fast responsive superporous hydrogels
TLDR
This work has prepared superporous hydrogels (SPHs) that can swell or shrink extremely fast regardless of their dimensions, and these materials can be used for applications where a single-piecehydrogel is more advantageous than hydrogel microparticulates.
Experimental Design for the Synthesis of Polyacrylamide Superporous Hydrogels
An experimental design, based on L-18 Taguchi matrix, was used to examine the influence of formulation ingredients on a variety of aspects of gel formation during the synthesis of polyacrylamide…
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