Recent developments in structure-based drug design

@article{Klebe2000RecentDI,
  title={Recent developments in structure-based drug design},
  author={G. Klebe},
  journal={Journal of Molecular Medicine},
  year={2000},
  volume={78},
  pages={269-281}
}
  • G. Klebe
  • Published 2000
  • Chemistry, Medicine
  • Journal of Molecular Medicine
Abstract. Structure-based design has emerged as a new tool in medicinal chemistry. A prerequisite for this new approach is an understanding of the principles of molecular recognition in protein-ligand complexes. If the three-dimensional structure of a given protein is known, this information can be directly exploited for the retrieval and design of new ligands. Structure-based ligand design is an iterative approach. First of all, it requires the crystal structure or a model derived from the… Expand
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