Recent developments in chemical diversity

  title={Recent developments in chemical diversity},
  author={John A. Porco},
  journal={Beilstein Journal of Organic Chemistry},
  pages={827 - 828}
  • J. Porco
  • Published 6 June 2012
  • Medicine
  • Beilstein Journal of Organic Chemistry
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactamor lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation. Introduction In comparison with the well-known β-carbolines, α-carboline…