Recent developments in antiandrogens and selective androgen receptor modulators.

  title={Recent developments in antiandrogens and selective androgen receptor modulators.},
  author={Bernard Haendler and Arwed Cleve},
  journal={Molecular and cellular endocrinology},
  volume={352 1-2},
The androgens testosterone and dihydrotestosterone play an essential role in the development and maintenance of primary and secondary male characteristics. Androgens bind to a specific androgen receptor (AR), a ligand-dependent transcription factor which controls the expression of a large number of downstream target genes. The AR is an essential player in early and late prostate cancer, and may also be involved in some forms of breast cancer. It also represents a drug target for the treatment… CONTINUE READING
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