Recent developments in HIV and the kidney

@article{Post2009RecentDI,
  title={Recent developments in HIV and the kidney},
  author={Frank A Post and Stephen G. Holt},
  journal={Current Opinion in Infectious Diseases},
  year={2009},
  volume={22},
  pages={43–48}
}
  • F. Post, S. Holt
  • Published 2009
  • Medicine
  • Current Opinion in Infectious Diseases
Purpose of review Antiretroviral therapy has been immensely successful in reducing the incidence of opportunistic infections and death after HIV infection. This has resulted in heightened interest in noninfectious comorbidities including kidney disease. This review focuses on recent progress in our understanding of the clinical epidemiology of HIV-associated kidney disease. Recent findings Acute renal failure in the highly active antiretroviral therapy era is associated with delayed HIV… Expand
Rapid recovery of renal function after pulse steroid therapy in a human immunodeficiency virus‐infected patient with glomerulonephritis
TLDR
This work describes an HIV-infected patient with acute kidney injury secondary to anti-neutrophil cytoplasm antibody (ANCA)-negative pauci-immune mesangial proliferative glomerulonephritis on a background of acute tubular necrosis, with rapid response to treatment with steroid therapy. Expand
Renal complications in HIV disease: between present and future.
TLDR
This review addresses the various aspects of the epidemiology of renal damage, the interaction and the convergent effect of HIV and antiretroviral drugs in the onset of kidney injury, the interplay between kidney function and other organ systems, early clinical management, the monitoring of renal function, and a proposal of clinical approach to kidney disease in daily practice. Expand
Kidney failure during HIV disease treated with tenofovir, multiple concurrent diseases and drug therapies
TLDR
The expected interactions between antiretroviral therapy and the even growing exposure to multiple different drug and drug classes, which may be responsible for relevant drug interactions and direct or adjunctive end-organ impairment, up to life-threatening conditions are discussed. Expand
Contemporary issues and new challenges in chronic kidney disease amongst people living with HIV
TLDR
Kidney transplantation amongst PLWHIV is successful and associated with an improved prognosis compared to remaining on dialysis, and the potential nephrotoxicity of ART is important, particularly as cumulative ART exposure increases as the cohort ofPLWHIV ages. Expand
HIV-associated kidney disease in the context of an aging population.
TLDR
HIV care increasingly needs to incorporate strategies to detect and manage these non-infectious co-morbidities, and several studies have shown age to be a risk factor for HIV-associated kidney disease. Expand
Kidney tubular damage in the absence of glomerular defects in HIV-infected patients on highly active antiretroviral therapy.
TLDR
A quarter of HIV-infected patients receiving HAART had subclinical tubular damage, which was associated with a near-term decline in eGFR and higher incidence of proteinuria, and periodic monitoring of urinary biomarkers might facilitate the early identification of HAART patients predisposed to significant kidney disease. Expand
Antiretroviral Treatment (ART) of Adult HIV Infection
TLDR
Mortality from non-AIDS events now exceeds that of AIDS-defining opportunistic diseases in individuals receiving ART, and the risks associated with ART have decreased, whereas concerns regarding the risks of long-standing untreated viremia have increased. Expand
[Assessment and management of kidney disease in the HIV-1-infected patient. A practical review].
TLDR
As a practical contribution to the management of HIV-1-associated renal dysfunction, guidelines are proposed for assessing the most common kidney-related problems and their management in daily practice. Expand
Clinical Characteristics of Kidney Disease in Japanese HIV-Infected Patients
TLDR
The international dimension of the burden of kidney disease in HIV-infected patients has been shown, with significant associations between increasing levels of serum creatinine and cholesterol, and the coexistence of diabetes, hypertension and hepatitis C coinfection with either proteinuria or albuminuria, which was significantly related to the presence of renal dysfunction. Expand
Secondary complications and co-infections in the HIV-infected adolescent in the antiretroviral era
TLDR
Assessing and addressing the risk of secondary complications and co-infections in the HIV-infected adolescent is crucial for optimal length and quality of life. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 75 REFERENCES
HIV-1 infection and the kidney: an evolving challenge in HIV medicine.
TLDR
HIV-positive individuals who experience progression to end-stage renal disease and who have undetectable HIV-1 viral loads while receiving HAART should be evaluated for renal transplant, and emerging evidence suggests that HIV- positive individuals may have graft and patient survival comparable to HIV-negative individuals. Expand
Predictors of renal outcome in HIV-associated nephropathy.
  • F. Post, L. Campbell, +23 authors P. Easterbrook
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2008
TLDR
No additional renal benefit of early initiation of highly active antiretroviral therapy or viral suppression could be demonstrated in this large cohort of patients with established HIVAN, and Severity of chronic kidney damage, as quantified by biopsy, was the strongest predictor of renal outcome. Expand
The nephrologist in the HAART era.
TLDR
The burden of comorbid chronic kidney disease is likely to increase with ageing of the HIVinfected cohort, continued growth of the epidemic among susceptible minorities and increasing prevalence of HAART-related metabolic abnormalities. Expand
Low rates of antiretroviral therapy among HIV-infected patients with chronic kidney disease.
  • A. Choi, R. Rodriguez, +5 authors A. O'Hare
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
TLDR
Underexposure and inadequate dose adjustment of HAART may contribute to excess mortality among HIV-infected patients with CKD, with 22.5%-35.5% of the excess mortality found among patients with different levels of CKD found. Expand
Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya.
  • K. Wools-Kaloustian, Samir K Gupta, +7 authors M. Goldman
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2007
TLDR
Renal insufficiency is not uncommon, even in stable patients without diabetes or hypertension, and Utilizing resources to assess renal function prior to initiation of antiretrovirals in order to identify those likely to benefit from dosage adjustment is justified. Expand
The impact of HIV on chronic kidney disease outcomes.
TLDR
In this national CKD cohort, HIV-infected black patients were at higher risk of death, a similar risk for ESRD and loss of eGFR than black patients with diabetes, and HIV- Infected white patients experienced higher rates of death but a lower risk of ESRd than their counterparts with diabetes. Expand
Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease.
TLDR
Prevention of progression to ESRD should focus on early antiretroviral treatment of HIV-infected patients who have evidence ofAIDS-associated nephropathy, and an increase in HIV+ E SRD prevalence in the future is projected as a result of the increase in the AIDS population among black individuals. Expand
Antiretroviral therapy improves renal function among HIV-infected Ugandans.
TLDR
It is shown that renal dysfunction was common with advanced HIV disease in Uganda but this improved following 2 years of HAART, and in multivariable analysis, a baseline creatinine above 133 micromol/l, a weight gain of more than 5 kg over the 2 years, female gender and a WHO stage 4 classification were all associated with greater improvements in Creatinine clearance on HAART. Expand
Observations on a Cohort of HIV-Infected Patients Undergoing Native Renal Biopsy
TLDR
Findings in this study suggest that earlier renal biopsy may be warranted in HIV-infected patients, especially in light of the changing spectrum of renal disease in this group, and may reflect more severe acute and/or chronic disease at the time of biopsy. Expand
Chronic kidney disease prevalence and risk factors among HIV-infected patients.
TLDR
A cross-sectional study on HIV-infected patients at a university hospital in Barcelona, Spain, which recorded HIV exposure, HIV disease status according to the 1993 Centers for Disease Control and Prevention classification, exposure to antiretroviral treatment, and the factors associated with CKD found older age, female gender, hypertension, and diabetes mellitus. Expand
...
1
2
3
4
5
...