Recent developments in CCR2 antagonists.

  title={Recent developments in CCR2 antagonists.},
  author={Mingde Xia and Zhihua Sui},
  journal={Expert opinion on therapeutic patents},
  volume={19 3},
Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for monocytes and memory T cells by means of their binding to its specific cell-surface receptor, CC-chemokine receptor-2 (CCR2). CCR2 belongs to the G-protein-coupled seven-transmembrane receptor superfamily. The evidence in favor of CCR2 and MCP-1 having dominant roles in monocyte chemotaxis and chronic inflammation was provided by CCR2 and MCP-1 knockout mice. It has been recognized that CCR2 antagonists are potential… CONTINUE READING
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