Recent development of enterovirus A vaccine candidates for the prevention of hand, foot, and mouth disease

@article{Fang2018RecentDO,
  title={Recent development of enterovirus A vaccine candidates for the prevention of hand, foot, and mouth disease},
  author={Chih-Yeu Fang and Chia-Chyi Liu},
  journal={Expert Review of Vaccines},
  year={2018},
  volume={17},
  pages={819 - 831}
}
ABSTRACT Introduction: Hand, foot, and mouth disease (HFMD) is a childhood illness commonly caused by enterovirus A. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the most commonly identified viruses associated with HFMD. Recently, outbreaks caused by different enterovirus A including CV-A6 and CV-A10 are increasing. Being available now to protect against EV-A71 infection, inactivated EV-A71 vaccines cannot prevent coxsackievirus infections, thus limiting their general… 
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TLDR
Investigation of whole etiological spectrum following EV-A71 vaccination of approximate 40,000 infants and young children in Xiangyang demonstrated that six major serotypes of enteroviruses were co-circulating, including newly emergedCV-A2 and CV-A5, which are urgently needed for control of HFMD.
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