Recent applications of isotopic labeling for protein NMR in drug discovery.

@article{Hiroaki2013RecentAO,
  title={Recent applications of isotopic labeling for protein NMR in drug discovery.},
  author={Hidekazu Hiroaki},
  journal={Expert opinion on drug discovery},
  year={2013},
  volume={8 5},
  pages={523-36}
}
INTRODUCTION Nuclear magnetic resonance (NMR) applications in drug discovery are classified into two categories: ligand-based methods and protein-based methods. The latter is based on the observation of the (1)H-(15)N HSQC spectra of a protein with and without lead compounds. However, in order to take this strategy, isotopic labeling is an absolute necessity. Given that each (1)H-(15)N HSQC signal corresponds to a residue of the target protein, signal changes provide specific information on… CONTINUE READING
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A Truncated HIV - 1 tat protein basic domain rapidly translocates through Recent applications of isotopic labeling for protein NMR in drug discovery Expert Opin

  • E Vives
  • Drug Discov
  • 2013

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