Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB.

Abstract

The transcription factor, nuclear factor-kappaB (NF-kappaB) has been studied extensively due to its prominent role in the regulation of immune and inflammatory genes, apoptosis, and cell proliferation. It has been known for more that a decade that NF-kappaB is a redox-sensitive transcription factor. The contribution of redox regulation and the location of… (More)

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@article{JanssenHeininger2000RecentAT, title={Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB.}, author={Yvonne M. W. Janssen-Heininger and Matthew E. Poynter and Patrick A. Baeuerle}, journal={Free radical biology & medicine}, year={2000}, volume={28 9}, pages={1317-27} }