Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies.

@article{Mimeault2008RecentAO,
  title={Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies.},
  author={Murielle Mimeault and Ralph J. Hauke and Surinder Batra},
  journal={Clinical pharmacology and therapeutics},
  year={2008},
  volume={83 5},
  pages={673-91}
}
This review summarizes the recent knowledge obtained on the molecular mechanisms involved in the intrinsic and acquired resistance of cancer cells to current cancer therapies. We describe the cascades that are often altered in cancer cells during cancer progression that may contribute in a crucial manner to drug resistance and disease relapse. The emphasis is on the implication of ATP-binding cassette (ABC) multidrug efflux transporters in drug disposition and antiapoptotic factors, including… CONTINUE READING
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