Recent advances in understanding the antibacterial properties of flavonoids.

@article{Cushnie2011RecentAI,
  title={Recent advances in understanding the antibacterial properties of flavonoids.},
  author={Tim Cushnie and Andrew J Lamb},
  journal={International journal of antimicrobial agents},
  year={2011},
  volume={38 2},
  pages={
          99-107
        }
}
  • Tim Cushnie, A. Lamb
  • Published 1 August 2011
  • Biology
  • International journal of antimicrobial agents

Prospect of Plant-based Flavonoids to Overcome Antibacterial Resistance: A Mini-Review

TLDR
The potency of flavonoids as antibacterial compound including their mechanism of antibacterial action as well as the relationship between their activity and flavonoid structure is presented and the synergistic effect of Flavonoids when used in combination with antibiotics against resistant bacterial is described.

Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities.

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

TLDR
This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure–activity relationship and mechanisms of actions of this broad class of natural compounds.

Comprehensive review of antimicrobial activities of plant flavonoids

TLDR
The development and application of flavonoid-based drugs could be a promising approach for antibiotic-resistant infections and improve understanding of the biological and molecular roles of plant flavonoids, focusing mostly on their antimicrobial activities.

Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains

TLDR
Most recent reports on antimicrobial action of polyphenols on Staphylococcus aureus strains are described, highlighting where proven, the mechanisms of action and the structure–activity relationships.

A novel synthetic flavonoid with potent antibacterial properties: In vitro activity and proposed mode of action

TLDR
The potent in vitro antibacterial activity of ClCl-flav—a novel synthetic tricyclic flavonoid shows significantly enhanced antibacterial activities, 32 to 72-fold more active than other synthetic flavonoids.

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery.

TLDR
Key findings on the antibacterial potential of plant NPs are brought to the forefront for consideration in future antibiotic discovery and development efforts.

Phytochemicals with activity against methicillin-resistant Staphylococcus aureus.

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

TLDR
An overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins is presented, demonstrating the great potential of flavonoid in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.
...

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Antimicrobial activity of flavonoids

Antiviral and Antimicrobial Assessment of Some Selected Flavonoids

TLDR
All of the compounds tested were found to be quite active against S. aureus and E. faecalis, and only compound 3 displayed an antiviral effect towards PI-3 in the range of 8- 32 μg/ml of inhibitory concentration for cytopathogenic effect (CPE).

Antibacterial activity of flavonoids against methicillin-resistant Staphylococcus aureus strains.

TLDR
It is concluded that the flavonoids chalcone, 2'(OH)-chal cone, 2',4'( OH)(2)-chalcone and 2,4(OH)(2-chalcone) might constitute promising therapeutic agents against infections with methicillin-resistant S. aureus strains.

Medicinal plants and antimicrobial activity.

Antibacterial mechanism of soybean isoflavone on Staphylococcus aureus

TLDR
The results indicate that topoisomerase I and II are the most important targets by SI to restrain bacterial cell division.

Antimicrobial properties of green tea catechins.

TLDR
Evidence is emerging that these molecules may be useful in the control of common oral infections, such as dental caries and periodontal disease and it is likely that they affect both virulence and antibiotic resistance by perturbing the function of key processes associated with the bacterial cytoplasmic membrane.

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TLDR
The time-kill study results indicated a low synergistic effect against 3 test strains, which suggests the mixture of GAL and GEN could lead to the development of new combination antibiotics against MRSA infection.

Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas

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    Molecular nutrition & food research
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TLDR
This overview surveys and interprets the present knowledge of activities of tea flavonoids and teas against foodborne and other pathogenic bacteria, virulent protein toxins produced by some of the bacteria,virulent bacteriophages, pathogenic viruses and fungi and the synergistic, mechanistic, and bioavailability aspects of the antimicrobial effects.
...