Recent advances in thiopeptide antibiotic biosynthesis.

@article{Li2010RecentAI,
  title={Recent advances in thiopeptide antibiotic biosynthesis.},
  author={Chaoxuan Li and Wendy L Kelly},
  journal={Natural product reports},
  year={2010},
  volume={27 2},
  pages={
          153-64
        }
}
Thiopeptides, or thiazolylpeptides, are a family of highly modified peptide antibiotics first discovered several decades ago. Dozens of thiopeptides have since been identified, but, until recently, the biosynthetic genes responsible for their production remained elusive. The biosynthetic systems for a handful of thiopeptide metabolites were identified in the first portion of 2009. The surprising finding that these metabolites arise from the enzymatic tailoring of a simple, linear, ribosomally… CONTINUE READING
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