Recent advances in the understanding of mastocytosis: the role of KIT mutations *

@article{Orfao2007RecentAI,
  title={Recent advances in the understanding of mastocytosis: the role of KIT mutations *},
  author={A. Orfao and A. Garc{\'i}a-Montero and Laura S{\'a}nchez and L. Escribano},
  journal={British Journal of Haematology},
  year={2007},
  volume={138}
}
Mastocytosis is a heterogeneous disorder characterised by the expansion and accumulation of mast cells in different organs and tissues. Mast cell physiology is closely dependent on activation of the stem cell factor/Kit signalling pathways and accumulating evidences confirm the physiopathological key role of activating KIT mutations (typically D816V) in mastocytosis and their relationship with the clinical manifestations of the disease. This paper reviews the most recent advances in the… Expand
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