Recent advances in the understanding of biological implications and modulation methodologies of monoclonal antibody N-linked high mannose glycans.

@article{Shi2014RecentAI,
  title={Recent advances in the understanding of biological implications and modulation methodologies of monoclonal antibody N-linked high mannose glycans.},
  author={Helen H Shi and Chetan T. Goudar},
  journal={Biotechnology and bioengineering},
  year={2014},
  volume={111 10},
  pages={1907-19}
}
With the prevalence of therapeutic monoclonal antibodies (mAbs) in the biopharmaceutical industry, the use of mammalian cell culture systems, particularly Chinese hamster ovary (CHO) cells, has become the main method for the production of therapeutics. Despite their similarity to human cells, one major challenge of mammalian cell based biopharmaceutical… CONTINUE READING