Recent advances in the understanding and management of delayed puberty

@article{Wei2015RecentAI,
  title={Recent advances in the understanding and management of delayed puberty},
  author={Christina Wei and Elizabeth C. Crowne},
  journal={Archives of Disease in Childhood},
  year={2015},
  volume={101},
  pages={481 - 488}
}
Delayed puberty, especially in boys, is a common presentation in paediatrics. Recent advances have improved our understanding of the neuroendocrine, genetic and environmental factors controlling pubertal development, and hence inform the pathophysiology of delayed puberty. The discovery of kisspeptin signalling through its receptor identified neuroendocrine mechanisms controlling the gonadotrophin-releasing hormone (GnRH) pulse generator at the onset of puberty. Genetic mechanisms from single… 

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Disorders of puberty.

Timing of Pubertal Onset in Girls and Boys with Constitutional Delay.

TLDR
A broad range of ages at pubertal entry for children with constitutional delay challenges the concept that constitutional delay is merely an extreme of normal variation and should consider the possibility that some children may need to wait years after presentation until puberty starts.

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TLDR
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