Recent advances in the nutritional biochemistry of trivalent chromium

@article{Vincent2004RecentAI,
  title={Recent advances in the nutritional biochemistry of trivalent chromium},
  author={John B. Vincent},
  journal={Proceedings of the Nutrition Society},
  year={2004},
  volume={63},
  pages={41 - 47}
}
  • J. Vincent
  • Published 1 February 2004
  • Chemistry, Medicine
  • Proceedings of the Nutrition Society
The nutritional biochemistry of trivalent Cr has been a poorly understood field of study; investigations of the biochemistry of the other essential transition metals have not proven as problematic. Despite over four decades of endeavour, only recently has a picture of the role of Cr potentially started to be defined. The biologically-relevant form is the trivalent ion. Cr3+ appears to be required for proper carbohydrate and lipid metabolism in mammals, although fortunately Cr deficiency is… 
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The nutritional biochemistry of chromium (III)
Chapter 1. Introduction: A History of Chromium Studies (1955-1995)(J.B. Vincent, D. Stallings). Part I. Chromium as a Nutrient and Nutritional Supplement Chapter 2. Basis for Dietary Recommendations
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References

SHOWING 1-10 OF 87 REFERENCES
The biochemistry of chromium.
  • J. Vincent
  • Chemistry, Medicine
    The Journal of nutrition
  • 2000
TLDR
The oligopeptide chromodulin appears to play a role in an autoamplification mechanism in insulin signaling, and the molecular agent responsible for transporting chromium from mobile pools to insulin-sensitive cells is probably the metal transport protein transferrin.
The bioinorganic chemistry of chromium(III)
Abstract The biochemistry of chromium(III) has been a poorly understood field of endeavor. Despite four decades of investigation, only recently has a somewhat clear picture of the role of Cr been
In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplement.
TLDR
The tissue distribution, urinary and fecal loss, and subcellular hepatocyte distribution and concentration of the labels suggest that [Cr(pic)(3)] has a lifetime of less than 1 day in vivo, minimizing the potential threat from the supplement itself.
The Potential Value and Toxicity of Chromium Picolinate as a Nutritional Supplement, Weight Loss Agent and Muscle Development Agent
TLDR
Over a decade of human studies with Cr(pic)3 indicate that the supplement has not demonstrated effects on the body composition of healthy individuals, even when taken in combination with an exercise training programme.
The trail of chromium(III) in vivo from the blood to the urine: the roles of transferrin and chromodulin
TLDR
Increases in urinary chromium loss in response to insulin are reflected by increases in chromodulin, establishing a direct link between carbohydrate metabolism and the oligopeptide.
The nutritional supplement chromium(III) tris(picolinate) cleaves DNA.
TLDR
This study suggests that investigation of the long-term effects of supplementation of the diet with Cr(pic)3 are needed to assess the safety of this material.
Lack of toxicity of chromium chloride and chromium picolinate in rats.
TLDR
A lack of toxicity of trivalent Cr is demonstrated, at levels that are on a per kg basis, several thousand times the upper limit of the estimated safe and adequate daily dietary intake for humans.
Isolation of a biologically active low-molecular-mass chromium compound from rabbit liver.
TLDR
It is suggested that LMCr plays essential roles in both glucose metabolism and detoxification of invaded Cr in the body.
The nutritional supplement chromium picolinate generates oxidative DNA damage and peroxidized lipids in vivo
Abstract The nutritional supplement chromium picolinate, [Cr(pic)3], has been proposed to damage DNA, presumably through the catalytic formation of reactive oxygen species. For this mechanism to be
Quest for the molecular mechanism of chromium action and its relationship to diabetes.
TLDR
The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a novel insulin-signaling autoamplification mechanism that sheds some light on the potential ofchromium-containing compounds as nutritional supplements or in the treatment of adult-onset diabetes and other conditions.
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