Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.

@article{Len2013RecentAI,
  title={Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.},
  author={Rafael Le{\'o}n and Antonio G Garc{\'i}a and Jos{\'e} Marco-Contelles},
  journal={Medicinal research reviews},
  year={2013},
  volume={33 1},
  pages={139-89}
}
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to nations. Unless a new medicine capable to delay disease progression is found, the number of cases will reach 107 million in 2050. So far, the therapeutic paradigm one-compound-one-target has failed. This could be due to the multiple pathogenic mechanisms involved in AD including amyloid β (Aβ) aggregation to form plaques… CONTINUE READING
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