Recent advances in the molecular pathophysiology of atrial fibrillation.

  title={Recent advances in the molecular pathophysiology of atrial fibrillation.},
  author={Reza Wakili and Niels Voigt and Stefan K{\"a}{\"a}b and Dobromir Dobrev and Stanley Nattel},
  journal={The Journal of clinical investigation},
  volume={121 8},
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the… CONTINUE READING
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