Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs).

  • Anton M Jetten
  • Published 2004 in Current drug targets. Inflammation and allergy


Retinoid-related orphan receptors ROR alpha, -beta, and -gamma are evolutionarily related transcription factors belonging to the steroid hormone receptor superfamily. Studies of ROR mutant mice revealed that these receptors are critical in the regulation of a number of physiological processes. ROR alpha plays a key role in the development of the cerebellum… (More)