Recent advances in the field of caloric restriction mimetics and anti-aging molecules

  title={Recent advances in the field of caloric restriction mimetics and anti-aging molecules},
  author={Jan Martel and Shih-Hsin Chang and Cheng-Yeu Wu and Hsin-Hsin Peng and Tsong-Long Hwang and Yun-Fei Ko and John D. Young and David M. Ojcius},
  journal={Ageing Research Reviews},

Caloric Restriction Mimetics in Nutrition and Clinical Trials

Dietary sources, availability and intake levels of dietary Caloric Restriction Mimetics (CRMs), and a summary of their effects in clinical trials are discussed.

Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy

CR has a huge impact on promoting longevity by delaying the severity and the onset of inflammatory and several age-related diseases including obesity, cardiovascular, neurodegenerative and ophthalmic disorders, and cancer.

Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment

This review aims to put rapamycin under the spot and highlight its discovery, famous microbial producers, reported biological activities, chemical structure, famous analogues, and biosynthesis, and discuss future prospects of this potent drug.

Organ-differential Roles of Akt/FoxOs Axis as a Key Metabolic Modulator during Aging

It is demonstrated that age-dependent suppression of Akt increases the activity of FoxOs (Akt/FoxOs axis upregulation) in metabolic organs such as liver and muscle, which could be modulated and reversed by antiaging paradigm calorie restriction (CR).

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

This review highlights the underlying mechanisms and signs of MSC cellular senescence, and discusses the strategies to combat aging and cellularsenescence.

Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway

It is revealed that metformin promoted osteogenic differentiation and H2O2-induced oxidative damage of osteoblasts via the PI3K/AKT/Nrf2/HO-1 pathway and could improve bone mass and oxidative level of OVX mice.

Insights into the Anti-Aging Prevention and Diagnostic Medicine and Healthcare

This review intends to explore and characterize various applications related to anti-aging medicine and healthcare in the elderly, from health checkups to alternative medicine and biophysical technology beyond simple clinical medicine, and are being applied to demand the needs of the elderly.

Furanoditerpenes from Spongia (Spongia) tubulifera Display Mitochondrial-Mediated Neuroprotective Effects by Targeting Cyclophilin D.

Results indicate that furanoditerpenes 1-5 have mitochondrial-mediated neuroprotective properties through direct interaction with cyclophilin D, and compounds are promising drugs for new therapeutic strategies against neurodegeneration.

An essay on the nominal vs. real definitions of aging

Ageing research is concerned with the elucidation of the pathways and mechanisms that link aging defined as above to its hallmarks and manifestations, including those comprised by its nominal definitions.

PLA2G7, caloric restriction and cardiovascular aging

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (, which permits unrestricted



Caloric restriction mimetics: towards a molecular definition

A unifying definition of CRMs is proposed as compounds that stimulate autophagy by favouring the deacetylation of cellular proteins in order to have health-promoting and lifespan-extending effects.

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.

Findings indicate that TETA induces autophagy through a novel mode of action, namely, by the activation of an AcCoA-depleting enzyme.

Anti-obesogenic and antidiabetic effects of plants and mushrooms

The molecular mechanisms that underlie the anti-obesogenic and antidiabetic effects of several plants and mushrooms contain antioxidants, fibre and other phytochemicals, and it is proposed that combining these food items with existing anti-OBesogenic approaches might help to reduce obesity and its complications.

Chemical activation of SAT1 corrects diet-induced metabolic syndrome

The finding that triethylenetetramine dihydrochloride (TETA), a copper-chelator agent that can be safely administered to patients for the long-term treatment of Wilson disease, exerts therapeutic benefits in animals challenged with hypercaloric dietary regimens is reported.

Resveratrol improves health and survival of mice on a high-calorie diet

It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.

Hormetic Effects of Phytochemicals on Health and Longevity