Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.

  title={Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.},
  author={{\'A}gnes Telbisz and L{\'a}szl{\'o} Homolya},
  journal={Expert opinion on therapeutic targets},
  volume={20 4},
INTRODUCTION The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile. A range of human diseases is associated with the malfunction of BSEP, including fatal hereditary liver disorders and mild cholestatic conditions. Manifestation of these diseases primarily depends on the mutation type; however, other factors such as hormonal changes and drug interactions can also trigger or influence the related diseases… CONTINUE READING


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