Recent advances in the discovery and delivery of vaccine adjuvants

  title={Recent advances in the discovery and delivery of vaccine adjuvants},
  author={Derek T O'hagan and Nicholas M. Valiante},
  journal={Nature Reviews Drug Discovery},
Adjuvant design has historically had a touch of alchemy at its heart due to its reliance on the complex biology of innate immune activation. However, a new mechanistic understanding of innate immunity, combined with new adjuvant and delivery platforms for exploiting this knowledge, has led to significant advances recently. Although many challenges remain, the field is moving rapidly and the proper tools and methodologies are in place for the use of traditional drug discovery engines in guiding… CONTINUE READING


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Mutants of the Escherichia coli heatlabile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines

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