Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis

@inproceedings{Bode2012RecentAI,
  title={Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis},
  author={Sebastian F N Bode and Kai Lehmberg and Andrea Maul-Pavicic and Thomas Vraetz and Gritta E. Janka and Udo zur Stadt and Stephan Ehl},
  booktitle={Arthritis research & therapy},
  year={2012}
}
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of activated lymphocytes and macrophages secreting high amounts of inflammatory cytokines. It is a frequent manifestation in patients with predisposing genetic defects, but can occur secondary to various infectious, malignant, and autoimmune triggers in patients without a known genetic predisposition. Clinical hallmarks are prolonged fever, cytopenias… CONTINUE READING
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