Recent advances in the diagnosis and treatment of heparin-induced thrombocytopenia.

@article{Bakchoul2012RecentAI,
  title={Recent advances in the diagnosis and treatment of heparin-induced thrombocytopenia.},
  author={Tamam Bakchoul and Andreas Greinacher},
  journal={Therapeutic advances in hematology},
  year={2012},
  volume={3 4},
  pages={
          237-51
        }
}
Heparin-induced thrombocytopenia (HIT) is a drug-mediated, prothrombotic disorder caused by immunization against platelet factor 4 (PF4) after complex formation with heparin or other polyanions. After their binding to PF4/heparin complexes on the platelet surface, HIT antibodies are capable of intravascular platelet activation by cross-linking Fcγ receptor IIA leading to a platelet count decrease and/or thrombosis. Diagnosis of HIT is often difficult. This, and the low specificity of the… CONTINUE READING
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