Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor.

@article{Marriott2008RecentAI,
  title={Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor.},
  author={Karla-Sue C. Marriott and John W. Huffman},
  journal={Current topics in medicinal chemistry},
  year={2008},
  volume={8 3},
  pages={
          187-204
        }
}
Two subtypes of the mammalian cannabinoid receptor have been identified and successfully cloned since 1990. The CB(1) receptor is primarily located in the central nervous system and the CB(2) receptor is almost exclusively expressed in cells of the immune system. The CB(1) and CB(2) receptors are both G-protein coupled receptors and are involved in the inhibition of adenylate cyclase. The CB(2) receptor is of particular importance due to its involvement in signal transduction in the immune… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Cannabinoid signaling in health and disease.

Canadian journal of physiology and pharmacology • 2017
View 4 Excerpts
Highly Influenced

Bath salts and other emerging toxins.

Pediatric emergency care • 2014
View 2 Excerpts

Similar Papers

Loading similar papers…