Recent advances in the development of selective androgen receptor modulators

@article{Zhang2009RecentAI,
  title={Recent advances in the development of selective androgen receptor modulators},
  author={Xuqing Zhang and J. Lanter and Z. Sui},
  journal={Expert Opinion on Therapeutic Patents},
  year={2009},
  volume={19},
  pages={1239 - 1258}
}
Background: The androgens testosterone and its more potent tissue metabolite 5-α-dihydrotesterone regulate diverse physiological process involving both reproductive and non-reproductive functions. Most of the signaling effects of androgens are mediated through the androgen receptor (AR), a member of the nuclear receptor superfamily of transcription factors. The AR has been a target for drug development focused on the treatment of pathological conditions arising from abnormal androgen levels or… Expand
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