Recent advances in the cellular and molecular biology of mast cells.

@article{Stevens1989RecentAI,
  title={Recent advances in the cellular and molecular biology of mast cells.},
  author={Richard L. Stevens and K Frank Austen},
  journal={Immunology today},
  year={1989},
  volume={10 11},
  pages={381-6}
}
The mast cell is now considered to play a pivotal role not only in allergic reactions but also in a number of inflammatory disorders. After immunological activation via the IgE receptor, the mast cell releases a variety of cytokines, lipid-derived mediators, amines, proteases and proteoglycans--all of which can regulate adjacent cells and the metabolism of the extra-cellular matrix of connective tissues. While it had been known for some time that mast cells differ in a number of properties in… CONTINUE READING