Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.

@article{Kappe2000RecentAI,
  title={Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.},
  author={C. Oliver Kappe},
  journal={Accounts of chemical research},
  year={2000},
  volume={33 12},
  pages={
          879-88
        }
}
  • C. Kappe
  • Published 28 September 2000
  • Chemistry
  • Accounts of chemical research
In 1893, P. Biginelli reported the synthesis of functionalized 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea, and ethyl acetoacetate. In the past decade, this long-neglected multicomponent reaction has experienced a remarkable revival, mainly due to the interesting pharmacological properties associated with this dihydropyrimidine scaffold. In this Account, we highlight recent developments in the Biginelli reaction in areas such… 
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