Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo

@inproceedings{Benesch2016RecentAI,
  title={Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo},
  author={Matthew G K Benesch and Xiaoyun Tang and Ganesh Venkatraman and Raie T. Bekele and David N. Brindley},
  booktitle={Journal of biomedical research},
  year={2016}
}
Extracellular lysophosphatidate (LPA) is a potent bioactive lipid that signals through six G-protein-coupled receptors. This signaling is required for embryogenesis, tissue repair and remodeling processes. LPA is produced from circulating lysophosphatidylcholine by autotaxin (ATX), and is degraded outside cells by a family of three enzymes called the lipid phosphate phosphatases (LPPs). In many pathological conditions, particularly in cancers, LPA concentrations are increased due to high ATX… CONTINUE READING
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