Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.

@article{Moolman2014RecentAI,
  title={Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.},
  author={Wessel J A Moolman and Marianne de Villiers and Erick Strauss},
  journal={Biochemical Society transactions},
  year={2014},
  volume={42 4},
  pages={1080-6}
}
The biosynthesis and utilization of CoA (coenzyme A), the ubiquitous and essential acyl carrier in all organisms, have long been regarded as excellent targets for the development of new antimicrobial drugs. Moreover, bioinformatics and biochemical studies have highlighted significant differences between several of the bacterial enzyme targets and their… CONTINUE READING