Recent advances in studies on estrogen biosynthesis.

  title={Recent advances in studies on estrogen biosynthesis.},
  author={Angela M. H. Brodie},
  journal={Journal of endocrinological investigation},
  volume={2 4},
Studies show that aromatization (a reaction sequence unique in steroid biosynthesis) of androgens to estrogens is not limited to the female reproductive organs but also occurs in extragonadal tissue. Aromatization involves the loss of the angular C-19 methyl group and cis elimination of the 1beta and 2beta hydrogens from the androgen precursors, androstenedione and testosterone, to yield estrone and estradiol, respectively. In men, the production of estrone is 18 ug/day and is mainly… CONTINUE READING