Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives.

@article{Neu2005RecentAI,
  title={Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives.},
  author={Michael Neu and Dagmar Fischer and Thomas R. Kissel},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 8},
  pages={992-1009}
}
The continually increasing wealth of knowledge about the role of genes involved in acquired or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected cells a potentially promising strategy. Apart from viral vectors, non-viral gene delivery systems have recently received increasing interest, due to safety concerns associated with insertional mutagenesis of retro-viral vectors. Especially cationic polymers may be particularly attractive for the delivery of… CONTINUE READING